MRNA vs PFE: Moderna, Inc. vs Pfizer Inc. Historical Returns & Investment Comparison

This MRNA vs PFE comparison analyzes the historical stock performance of Moderna, Inc. and Pfizer Inc. side-by-side. Using real, adjusted market data, this tool shows how identical investments in both stocks would have performed over time—highlighting differences in annual returns and consistency across market cycles.

Use the interactive calculator below to adjust the investment amount and time period, visualizing how Moderna, Inc. and Pfizer Inc. have historically performed against each other.

Company Profiles

1

Moderna, Inc.

MRNA

Moderna, Inc. (MRNA) is a major public corporation operating in global financial and commercial markets. The company designs, produces, and markets key products, services, and operational solutions for consumer, enterprise, and industrial customers. Through continuous strategic investments in research, operational scaling, and market expansion, Moderna, Inc. maintains a prominent position within its industry sector.

Key Innovations

  • Integration of advanced data analytics and automation into core operational workflows.
  • Strategic R&D investment driving next-generation solution design and market differentiation.
  • Spikevax (COVID-19 vaccine)
  • mRNA technology platform
  • Proprietary technology architecture developed by Moderna, Inc. to optimize operational performance.
  • Expansion of digital transformation initiatives across product engineering and customer delivery.

Business Segments

  • Infectious Diseases
    COVID-19 vaccines, flu vaccines, RSV vaccines.
  • Oncology
    Personalized cancer vaccines.
  • Global Services & Support
    Comprehensive customer success, maintenance, and ongoing operational support services.
2

Pfizer Inc.

PFE

Pfizer Inc. (PFE) is a major public corporation operating in global financial and commercial markets. The company designs, produces, and markets key products, services, and operational solutions for consumer, enterprise, and industrial customers. Through continuous strategic investments in research, operational scaling, and market expansion, Pfizer Inc. maintains a prominent position within its industry sector.

Key Innovations

  • Comirnaty (COVID-19 vaccine)
  • Paxlovid (COVID-19 antiviral)
  • Proprietary technology architecture developed by Pfizer Inc. to optimize operational performance.
  • Integration of advanced data analytics and automation into core operational workflows.
  • Strategic R&D investment driving next-generation solution design and market differentiation.
  • Lipitor (historically highest selling drug)
  • Expansion of digital transformation initiatives across product engineering and customer delivery.

Business Segments

  • Primary Care
    Internal medicine, vaccines, and COVID-19 products.
  • Specialty Care
    Inflammation, immunology, rare diseases, and hospital products.
  • Oncology
    Cancer treatments (includes Seagen acquisition).

How This Comparison Works

Our stock comparison tool uses adjusted closing prices to calculate year-by-year returns for both stocks. This ensures an apples-to-apples comparison that accounts for:

  • Dividends: Prices are dividend-adjusted, reflecting the effect of dividend payments over time
  • Stock splits: Historical prices are adjusted for all splits
  • Head-to-head record: Shows which stock outperformed each year
  • Statistical analysis: Average returns, best/worst years, and win rates

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Important Disclaimer

This comparison tool is for educational and informational purposes only and does not constitute financial, investment, or trading advice. Past performance is not indicative of future results. Historical returns include dividends and stock splits but do not account for taxes, fees, inflation, or individual circumstances. Stock market investments carry risk, including the potential loss of principal. Always consult with a qualified financial advisor before making investment decisions. The data presented is based on historical market data and may contain inaccuracies or delays.