IQV vs SPY: IQVIA Holdings Inc. vs SPDR S&P 500 ETF Trust Historical Returns & Investment Comparison

This IQV vs SPY comparison analyzes the historical stock performance of IQVIA Holdings Inc. and SPDR S&P 500 ETF Trust side-by-side. Using real, adjusted market data, this tool shows how identical investments in both stocks would have performed over time—highlighting differences in annual returns and consistency across market cycles.

Use the interactive calculator below to adjust the investment amount and time period, visualizing how IQVIA Holdings Inc. and SPDR S&P 500 ETF Trust have historically performed against each other.

Company Profiles

IQVIA Holdings Inc.

IQV

IQVIA Holdings Inc. is a global leader in health information technology, advanced analytics, and clinical research services. Formed through the merger of Quintiles and IMS Health, it combines data-driven insights with clinical research excellence to provide integrated healthcare services, serving a broad range of clients within the life sciences industry.

Key Innovations

✓Development of 'IQVIA Connected Intelligence,' integrating high-quality health data, healthcare-grade AI, advanced analytics, and technology infrastructure to power insights.
✓Integration of advanced data analytics and automation into core operational workflows.
✓Strategic R&D investment driving next-generation solution design and market differentiation.
✓Proprietary technology architecture developed by IQVIA Holdings Inc. to optimize operational performance.
✓The strategic merger of IMS Health (specializing in pharmaceutical sales data) and Quintiles (a leader in clinical trials) to create a unique integrated healthcare service provider.
✓Expansion of digital transformation initiatives across product engineering and customer delivery.
✓A diverse service portfolio that includes innovative approaches to clinical development, real-world evidence generation, and commercialization strategies.

Business Segments

Technology & Analytics Solutions
Offers health information technology solutions, analytics consulting, and real-world solutions leveraging high-quality health data and AI.
Research & Development Solutions
Provides full-service contract research organization (CRO) services, managing all phases of clinical trials from early-stage to post-market studies.
Contract Sales & Medical Solutions
Delivers contract sales services, patient engagement solutions, and commercialization strategies for pharmaceutical and healthcare products.

SPDR S&P 500 ETF Trust

SPY

SPDR S&P 500 ETF Trust (SPY) is an exchange-traded fund managed by State Street Global Advisors that provides investors with targeted exposure to U.S. Large-Cap Equity by tracking the S&P 500 Index. The fund is structured to offer efficient, liquid, and low-cost access to its underlying asset class, utilizing continuous creation and redemption mechanisms to maintain tight alignment between market price and Net Asset Value (NAV). Widely utilized by institutional wealth managers, pension funds, and retail investors alike, SPY plays a central role in modern portfolio construction, asset allocation, and tactical risk management.

Key Innovations

✓Intra-day secondary market liquidity for benchmark S&P 500 Index exposure.
✓In-kind creation and redemption process mitigating embedded tax capital gains distributions.
✓Ultra-low expense ratio cost structure enabling compounding long-term investment returns.
✓Institutional-grade portfolio transparency with daily published holding disclosure.

Business Segments

Core Equity / Asset Portfolio
Direct holdings of underlying constituent securities comprising the S&P 500 Index.
Creation and Redemption Mechanism
Operational framework facilitating institutional Authorized Participants in exchanging basket securities for fund shares.
Securities Lending & Yield Optimization
Program generating incremental income by lending portfolio securities to institutional counterparties under collateralized agreements.

How This Comparison Works

Our stock comparison tool uses adjusted closing prices to calculate year-by-year returns for both stocks. This ensures an apples-to-apples comparison that accounts for:

✓Dividends: Prices are dividend-adjusted, reflecting the effect of dividend payments over time
✓Stock splits: Historical prices are adjusted for all splits
✓Head-to-head record: Shows which stock outperformed each year
✓Statistical analysis: Average returns, best/worst years, and win rates

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Important Disclaimer

This comparison tool is for educational and informational purposes only and does not constitute financial, investment, or trading advice. Past performance is not indicative of future results. Historical returns include dividends and stock splits but do not account for taxes, fees, inflation, or individual circumstances. Stock market investments carry risk, including the potential loss of principal. Always consult with a qualified financial advisor before making investment decisions. The data presented is based on historical market data and may contain inaccuracies or delays.