GILD vs SPY: Gilead Sciences Inc. vs SPDR S&P 500 ETF Trust Historical Returns & Investment Comparison
This GILD vs SPY comparison analyzes the historical stock performance of Gilead Sciences Inc. and SPDR S&P 500 ETF Trust side-by-side. Using real, adjusted market data, this tool shows how identical investments in both stocks would have performed over time—highlighting differences in returns, volatility, and consistency across market cycles.
Use the interactive calculator below to adjust the investment amount and time period, visualizing how Gilead Sciences Inc. and SPDR S&P 500 ETF Trust have historically performed against each other.
Compare Stock Performance
Select two stocks and an investment amount to see how they compare over time.
Compare any two stocks to see which performed better historically
Performance Summary
$10,000 invested from 1992 to 2025 (34 years)
Head-to-Head Record
Over the 33-year comparison period, Gilead Sciences Inc. outperformed SPDR S&P 500 ETF Trust in 19 years, while SPDR S&P 500 ETF Trust outperformed Gilead Sciences Inc. in 14 years.
GILD - Gilead Sciences Inc.
SPY - SPDR S&P 500 ETF Trust
Overall Winner: GILD with an average annual return of 25.22% (vs 11.71% for SPY)
Understanding GILD vs SPY Performance
When comparing Gilead Sciences Inc. and SPDR S&P 500 ETF Trust, investors should consider multiple factors beyond just total returns. Volatility, consistency of growth, dividend payments, and sector-specific risks all play crucial roles in determining which stock might be better suited for your investment strategy and risk tolerance.
Historical performance data shows how each stock responded to market downturns, economic expansions, and company-specific events. While past performance doesn't guarantee future results, understanding these patterns can help inform investment decisions and portfolio allocation strategies.
Cumulative Growth Comparison
A $10,000 investment in Gilead Sciences Inc. grew to $2,908,425, compared to $250,597 for SPDR S&P 500 ETF Trust over the same period.
Year-by-Year Comparison
| Year | GILD Return | GILD Cumulative | SPY Return | SPY Cumulative | Difference | Winner |
|---|---|---|---|---|---|---|
| 1992 (Start) | - | $10,000.00 | - | $10,000.00 | - | Initial Investment |
| 1993 | -4.94% | $9,506.17 | - | - | - | Tie |
| 1994 | -34.25% | $6,250.63 | +8.71% | $10,870.91 | -42.96% (SPY) | SPY |
| 1995 | -20.83% | $4,948.41 | +0.67% | $10,943.47 | -21.50% (SPY) | SPY |
| 1996 | +241.33% | $16,890.58 | +37.39% | $15,035.16 | +203.94% (GILD) | GILD |
| 1997 | -23.37% | $12,942.98 | +21.20% | $18,223.19 | -44.58% (SPY) | SPY |
| 1998 | +56.12% | $20,206.90 | +33.14% | $24,261.81 | +22.99% (GILD) | GILD |
| 1999 | +7.70% | $21,763.82 | +28.03% | $31,063.11 | -20.33% (SPY) | SPY |
| 2000 | +36.16% | $29,634.36 | +20.66% | $37,482.18 | +15.50% (GILD) | GILD |
| 2001 | +47.28% | $43,645.71 | -8.85% | $34,165.23 | +56.13% (GILD) | GILD |
| 2002 | +77.32% | $77,393.48 | -10.13% | $30,703.75 | +87.45% (GILD) | GILD |
| 2003 | +10.70% | $85,670.78 | -22.42% | $23,820.14 | +33.11% (GILD) | GILD |
| 2004 | +67.04% | $143,103.88 | +24.18% | $29,580.86 | +42.86% (GILD) | GILD |
| 2005 | +20.61% | $172,602.70 | +10.75% | $32,760.13 | +9.87% (GILD) | GILD |
| 2006 | +51.37% | $261,264.79 | +5.32% | $34,504.59 | +46.04% (GILD) | GILD |
| 2007 | +18.70% | $310,126.60 | +13.84% | $39,281.03 | +4.86% (GILD) | GILD |
| 2008 | +45.72% | $451,905.70 | +5.33% | $41,375.53 | +40.38% (GILD) | GILD |
| 2009 | +12.79% | $509,714.73 | -36.24% | $26,382.38 | +49.03% (GILD) | GILD |
| 2010 | -17.08% | $422,678.48 | +22.65% | $32,359.23 | -39.73% (SPY) | SPY |
| 2011 | -16.30% | $353,761.36 | +13.14% | $36,610.39 | -29.44% (SPY) | SPY |
| 2012 | +11.89% | $395,829.51 | +0.85% | $36,922.44 | +11.04% (GILD) | GILD |
| 2013 | +75.47% | $694,545.80 | +14.17% | $42,154.69 | +61.29% (GILD) | GILD |
| 2014 | +100.11% | $1,389,831.74 | +29.00% | $54,380.19 | +71.11% (GILD) | GILD |
| 2015 | +25.33% | $1,741,864.35 | +14.56% | $62,298.86 | +10.77% (GILD) | GILD |
| 2016 | +7.89% | $1,879,264.84 | +1.29% | $63,101.60 | +6.60% (GILD) | GILD |
| 2017 | -25.25% | $1,404,839.10 | +13.59% | $71,674.43 | -38.83% (SPY) | SPY |
| 2018 | -0.58% | $1,396,650.34 | +20.78% | $86,569.38 | -21.36% (SPY) | SPY |
| 2019 | -12.91% | $1,216,337.68 | -5.25% | $82,026.91 | -7.66% (SPY) | SPY |
| 2020 | +6.37% | $1,293,784.56 | +31.09% | $107,527.02 | -24.72% (SPY) | SPY |
| 2021 | -7.06% | $1,202,469.52 | +17.24% | $126,059.55 | -24.29% (SPY) | SPY |
| 2022 | +25.96% | $1,514,574.40 | +30.51% | $164,514.60 | -4.55% (SPY) | SPY |
| 2023 | +23.68% | $1,873,235.54 | -18.65% | $133,838.54 | +42.33% (GILD) | GILD |
| 2024 | -1.46% | $1,845,795.58 | +26.71% | $169,585.78 | -28.17% (SPY) | SPY |
| 2025 | +15.50% | $2,131,949.73 | +25.59% | $212,981.61 | -10.09% (SPY) | SPY |
| 2026 | +36.42% | $2,908,424.81 | +17.66% | $250,597.02 | +18.76% (GILD) | GILD |
Annual returns include dividends and stock splits. Cumulative values show growth of $10,000 invested from the first year. Positive difference means GILD outperformed SPY that year.
Company Profiles
Gilead Sciences Inc.
GILD
Gilead Sciences Inc. is a biopharmaceutical company that discovers, develops, and commercializes innovative medicines in areas of unmet medical need. The company's primary focus areas include HIV, liver diseases (hepatitis B and C), oncology, and inflammation. Gilead is committed to advancing science to improve the lives of patients worldwide, bringing forward transformative therapies that address challenging diseases and improve patient outcomes.
Key Innovations
- ✓Pioneered highly effective antiviral therapies that have transformed the treatment and prevention of HIV/AIDS.
- ✓Developed groundbreaking treatments for hepatitis C, achieving high cure rates and significantly impacting global public health.
Business Segments
- HIVDevelops and commercializes antiviral drugs for the treatment and prevention of HIV/AIDS.
- Liver DiseasesFocuses on therapies for chronic viral hepatitis, including hepatitis B and C.
- OncologyDevelops and commercializes treatments for various types of cancer.
SPDR S&P 500 ETF Trust
SPY
SPY is the first exchange-traded fund (ETF) listed in the US. It is designed to track the S&P 500 Index, which measures the performance of the large-cap segment of the US equity market.
Key Innovations
- ✓First US-listed ETF
Business Segments
- ETFPassive investment vehicle tracking the S&P 500.
How This Comparison Works
Our stock comparison tool uses adjusted closing prices to calculate year-by-year returns for both stocks. This ensures an apples-to-apples comparison that accounts for:
- ✓Dividends: All dividend payments are reinvested
- ✓Stock splits: Historical prices are adjusted for all splits
- ✓Head-to-head record: Shows which stock outperformed each year
- ✓Statistical analysis: Average returns, best/worst years, and win rates
Share This Comparison
People also compared
Important Disclaimer
This comparison tool is for educational and informational purposes only and does not constitute financial, investment, or trading advice. Past performance is not indicative of future results. Historical returns include dividends and stock splits but do not account for taxes, fees, inflation, or individual circumstances. Stock market investments carry risk, including the potential loss of principal. Always consult with a qualified financial advisor before making investment decisions. The data presented is based on historical market data and may contain inaccuracies or delays.