BIO vs SPY: Bio-Rad Laboratories, Inc. vs SPDR S&P 500 ETF Trust Historical Returns & Investment Comparison

This BIO vs SPY comparison analyzes the historical stock performance of Bio-Rad Laboratories, Inc. and SPDR S&P 500 ETF Trust side-by-side. Using real, adjusted market data, this tool shows how identical investments in both stocks would have performed over time—highlighting differences in returns, volatility, and consistency across market cycles.

Use the interactive calculator below to adjust the investment amount and time period, visualizing how Bio-Rad Laboratories, Inc. and SPDR S&P 500 ETF Trust have historically performed against each other.

Company Profiles

1

Bio-Rad Laboratories, Inc.

BIO

Bio-Rad Laboratories, Inc. is a multinational manufacturer and distributor of specialized technological products for the life science research and clinical diagnostics markets. The company provides a broad range of products, including instruments, software, consumables, and reagents, used to advance scientific discovery and improve healthcare.

Key Innovations

  • Pioneered the development of Bio-Gel P gel chromatography for protein separation.
  • Introduced the first commercially available T4 thyroid function test.
  • Developed Droplet Digital PCR technology, which allows for precise and sensitive quantification of nucleic acids.

Business Segments

  • Life Science
    Develops, manufactures, and markets a broad range of reagents, apparatus, and equipment for use in biological research and discovery.
  • Clinical Diagnostics
    Develops, manufactures, and markets a broad range of products for clinical diagnostics, including instruments, software, and reagents for disease screening, diagnosis, and monitoring.
2

SPDR S&P 500 ETF Trust

SPY

SPY is the first exchange-traded fund (ETF) listed in the US. It is designed to track the S&P 500 Index, which measures the performance of the large-cap segment of the US equity market.

Key Innovations

  • First US-listed ETF

Business Segments

  • ETF
    Passive investment vehicle tracking the S&P 500.

How This Comparison Works

Our stock comparison tool uses adjusted closing prices to calculate year-by-year returns for both stocks. This ensures an apples-to-apples comparison that accounts for:

  • Dividends: All dividend payments are reinvested
  • Stock splits: Historical prices are adjusted for all splits
  • Head-to-head record: Shows which stock outperformed each year
  • Statistical analysis: Average returns, best/worst years, and win rates

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Important Disclaimer

This comparison tool is for educational and informational purposes only and does not constitute financial, investment, or trading advice. Past performance is not indicative of future results. Historical returns include dividends and stock splits but do not account for taxes, fees, inflation, or individual circumstances. Stock market investments carry risk, including the potential loss of principal. Always consult with a qualified financial advisor before making investment decisions. The data presented is based on historical market data and may contain inaccuracies or delays.