BIIB vs SPY: Biogen Inc. vs SPDR S&P 500 ETF Trust Historical Returns & Investment Comparison

This BIIB vs SPY comparison analyzes the historical stock performance of Biogen Inc. and SPDR S&P 500 ETF Trust side-by-side. Using real, adjusted market data, this tool shows how identical investments in both stocks would have performed over time—highlighting differences in returns, volatility, and consistency across market cycles.

Use the interactive calculator below to adjust the investment amount and time period, visualizing how Biogen Inc. and SPDR S&P 500 ETF Trust have historically performed against each other.

Company Profiles

1

Biogen Inc.

BIIB

Biogen Inc. is an American multinational biotechnology company specializing in the discovery, development, and delivery of innovative therapies for people living with serious neurological and neurodegenerative diseases. The company focuses on conditions such as multiple sclerosis (MS), Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis (ALS), and spinal muscular atrophy (SMA).

Key Innovations

  • Pioneered the use of recombinant DNA technology in the biotechnology industry.
  • Developed Spinraza, the first approved treatment for spinal muscular atrophy (SMA).

Business Segments

  • Multiple Sclerosis
    Develops and commercializes therapies for multiple sclerosis.
  • Alzheimer's Disease and Dementia
    Focuses on research and development of treatments for Alzheimer's disease and related dementias.
  • Spinal Muscular Atrophy (SMA)
    Develops and commercializes therapies for spinal muscular atrophy.
2

SPDR S&P 500 ETF Trust

SPY

SPY is the first exchange-traded fund (ETF) listed in the US. It is designed to track the S&P 500 Index, which measures the performance of the large-cap segment of the US equity market.

Key Innovations

  • First US-listed ETF

Business Segments

  • ETF
    Passive investment vehicle tracking the S&P 500.

How This Comparison Works

Our stock comparison tool uses adjusted closing prices to calculate year-by-year returns for both stocks. This ensures an apples-to-apples comparison that accounts for:

  • Dividends: All dividend payments are reinvested
  • Stock splits: Historical prices are adjusted for all splits
  • Head-to-head record: Shows which stock outperformed each year
  • Statistical analysis: Average returns, best/worst years, and win rates

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Important Disclaimer

This comparison tool is for educational and informational purposes only and does not constitute financial, investment, or trading advice. Past performance is not indicative of future results. Historical returns include dividends and stock splits but do not account for taxes, fees, inflation, or individual circumstances. Stock market investments carry risk, including the potential loss of principal. Always consult with a qualified financial advisor before making investment decisions. The data presented is based on historical market data and may contain inaccuracies or delays.